Hypomagnesaemia in diabetic patients and biochemical action on the cardiovascular system

Abstract

Introduction: Diabetes Mellitus (DM) is a chronic disorder resulting from a number of factors in which an absolute or relative deficiency of insulin or its function occurs. It is projected that by the year 2025, India alone would have 57 million diabetics mainly of type 2 diabetes constituting 90% of the diabetic population. The most important risk factors contributing to the development of CHD include lipid disorders. Cardiovascular complications are the leading cause of mortality and morbidity in diabetics. Material Methods: In this study 40 subjects newly diagnosed with NIDDM, aged 35-55 years were selected. Among 39 subjects’ 20 are males and 20 were females.40 subjects of normal health individuals aged 35-55 years were selected for comparing with NIDDM subjects. 12hrs overnight fasting and a post pandrial venous blood samples were collected and separated by centrifugation at 2000 rpm for 10 min separated samples same day done for estimation of serum magnesium, lipid profile, FBS AND PPBS were measured by commercial kits. Statistics: P<0.05 statistically significant, using these methods the effect of diabetic control on the levels of serum magnesium in diabetic patients was studied with correlation parameters cholesterol, triglycerides, HDL. The difference between the groups were assessed by the student t test for independent samples. Linear regression analysis was done to know the association between the variables. Results: In diabetic patients serum cholesterol, triglycerides levels were higher than the healthy control levels. Discussion and Conclusion: Excess lipids in blood may lead to major complications like atherosclerosis, hypertension. Serum magnesium levels were found decreased comparing with controls. This may lead to myocardial ischemia, cardiac diseases. So magnesium levels could be a cause and consequences of DM and high levels of lipids may be lead to cardio vascular risk.