Significance of total creatine kinase and creatine kinase-mb levels in patients with acute myocardial infarction

Abstract

The aim of this study was to determine the significace of measuring total creatine kinase and creatine kinase-MB levels in the diagnosis of acute myocardial infarction.A strategy for diagnosing acute myocardial infarction was evaluated by studying 500 suspected patients aged 30-65 years. The control group,which included 200 subjects,was randomly selected from the casualty department. Investigations were carried out at Prince Rashid Bin Al-Hassan Military Hospital in the north region of jordan over one year period in 2009-2010 Total creatine kinase and creatin kinase-MB were measured in serum applying the creatine kinase,creatine kinase-MB NAC activated methods (Boehringer Mannheim’s) using the Hitashi -912 autoanalyzer. In acute myocardial infarction patients,the mean value of total creatine kinase was greater than that of normal range. Results of 25-900U/L for creatin kinase((for both sexes) were obtained at admission. Also the mean value of creatine kinase-MB(8-40U/L)and % cratine kinase-MB were geater than that of the normal range in both sexes. The maximum peak was found after 8-12 hours from the time of admission of myocardial infarction patients,both males and females. This study demonstrated that measurement of total creatine kinase and creatine kinase-MB is currently the test of choice to confirm the diagnosis of an acute myocardial infarction.Measurement of total creatine kinase and creatine kinase-MB every 8-12 hours is an adequate and costeffective method for the diagnosis of acute myocardial infarction. It was found that measurements of total creatin kinase and creatine kinase-MB are useful parameters for identifying people at high risk for acute myocardial infarction.