Orlistat and garlic curtailed antioxidant enzymes activities and ameliorated high fat diet induced obese sprague-dawley rats

Abstract

The global prevalence of obesity is on the increase, hence the development of a safer and more effective anti-obesity therapeutic approach is becoming more of an imperative. Objective: The study is to investigate whether Orlistat and Garlic can alter antioxidant property and lipid profile of high fat diet induced- obese Sprague-Dawley rats. Methods: Sixty–four albino Sprague-Dawley rats (170.62 ± 5.74g), were divided into two equal groups. Group A rats were fed with commercial chow diet, while group B rats were fed with chow and fat emulsion to induce obesity in rats for 30days. The rats in group B were divided into 4 groups of 8 rats each) and treated with Orlistat drug (5mg/kg body weight), Garlic extract (5ml) and a combination of both for 5 weeks. Results: Treatment with Orlistat and Garlic extracts and a combination of both significantly (p<0.01) reduced the lipid profile of the high fat induced obese rat. However, administration with Orlistat and Garlic in rats significantly (p<0.05) ameliorated hepatic and renal functions as observed in high-fat diet treated groups. Serum ALT, AST activities, LDL, triglycerides and total cholesterol levels were significantly (P<0.05) higher in the high fat group compared with control. Conclusion: Data of the study indicate that oral administration of Orlistat and / or Garlic extracts curtailed anti-oxidant enzymes activities and ameliorated high-fat diet induced obese Sprague-Dawley rats.