Wound healing evaluation of chloroform and methanolic extracts of mimosa pudica roots in rats

Abstract

Aim of the study: The roots of mimosa pudica (MP) are employed as folklore remedy for various types of wounds. The present research was carried out to evaluate wound-healing activity of chloroform (CEMP) and methanolic (MEMP) extracts of mimosa pudica roots in experimental models of animals. Methods: The wound healing evaluation was done using excision, incision, burn and dead space rat wound models. Aloe vera was used as standard wound healing agent. A formulation of CEMP and MEMP was prepared in carbopol and simple ointment respectively at 2.5% & 5% concentrations and applied topically to the wounds. Results: The observations from excision and burn wound models demonstrated that both CEMP and MEMP at high as well as low doses possess significant reduction in wound contraction and period of epithelization compared to control. In the incision wound model, a significant rise in breaking strength was observed in all treated group animals. Low and high doses of CEMP (100 and 500 mg/kg, p.o.) and MEMP (100 and 500 mg/kg, p.o.) produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue in dead space wound model. Conclusion: The results suggest that both CEMP and MEMP applied topically or administered orally possess wound-healing activity.